Rodent model of neuropathic pain is used to evaluate the efficacy of novel compounds. Since neuropathic pain occurs due to the neuronal injury, is a chronic condition thus it require the prolong treatment. In the present study the effect of pregabalin on chronic constriction injury (CCI) induced neuropathic pain model in SD rats (Sprague-dawley) during and after the treatment was first time examined. The majority of animals in CCI model exhibited characteristic neuropathic pain behaviors in all three nociceptive tests on postoperative day 5 and then maintained it during the whole study period. Pregabalin treatment was given from post operative day 7-13. Spontaneous pain and chemical allodynia were strongly attenuated by pregabalin (30 mg/kg, ip., bid.) during the whole treatment duration. Post treatment effect were maintained till post operative day 26 and 17 respectively, while mechanical hyperalgesia response was weakly attenuated only on post operative day 9. The effect of pregebalin on body weight, water intake and food intake insignificant was observed in all groups. All comparison was done using two tail unpaired t – test. Data were consider statistically significant at p value < 0.05, moderately significant at p value< 0.01 and highly significant at p value < 0.001. Overall, the results indicate that pregabalin was found to be effective in treatment of spontaneous pain and chemical allodynia conditions associated with neuropathic pain but the duration of therapy will be much longer.
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